Japanese

Zenganren × J-SUPPORT × SaQRA Research and Development Map
(R＆D Map) Address the unmet
needs in cancer survivorship.

Zenganren × J-SUPPORT × SaQRA Research and Development Map (R＆D Map)

Provide care that respects individual values to all who need it.

The Survivorship Care and Quality of Life Research Association (SaQRA) is developing treatments and care that focus on the central values of all individuals involved in cancer. Additionally, SaQRA is conducting research on implementing these treatments and care in social and clinical contexts and providing companion support.This R＆D map provides an overview of major research conducted within Japan and serves as a basis for planning research that addresses unmet needs.

  • Zenganren
  • J-SUPPORT
  • SaQRA
  • How is the R&D map created?
    We have collected information on research conducted by public research institutions and guidelines both in Japan and abroad regarding the 27 items*1 from the survey by Zenganren (Japan Federation of Cancer Patient Groups).
    According to the results of this survey and collected information, Zen-Ganren PPI committee, J-SUPPORT R&D map committee, and SaQRA held discussions and created the R&D map, which was published in February 2024.
  • What updates are coming?
    Items marked with "―" indicate those that had not been studied during the R&D map creation and require further research.

Definitions of the terms listed.

■Details of the intervention survey.
Solutions for issues requiring consideration.
■Research by public research funds in Japan.
Clinical trials and clinical research listed in clinical trial registration databases or public research funding databases.
  • MHLW ＝ Health and Labour Sciences Research Grant by the Ministry of Health, Labour and Welfare
  • AMED = Research funding provided by the Japan Agency for Medical Research and Development
  • KAKENHI = Grant-in-Aid for Scientific Research by the Japan Society for the Promotion of Science (JSPS)
■Guidelines in Japan
Clinical guidelines based on outcomes from the SaQRA guideline CQ review.
■Guidelines abroad
The “Guidelines abroad” section was created based on the following three guidelines:
  • NCCN Survivorship Guidelines 2022 TOC
  • NCCN Clinical Oncology Guidelines (e.g., Survivorship and others)
  • NCCN Clinical Oncology Guidelines for Patients

Important notes for viewing the R&D map

The R&D map is a conceptual diagram intended for efficiently planning clinical trials. Notably, it does not guarantee the comprehensiveness of important clinical issues, and the treatments and clinical trials shown should not be regarded as guidelines for individual patient treatment options.The study introduced on this page reflects the situation during map creation and may not be up to date.

  • This information is not intended to recruit patients for clinical trials. In addition, we cannot accept inquiries regarding the details of clinical trials conducted by other organizations that are introduced in the R&D map. Thank you for your understanding.

Research and Development Map
(R&D Map) FLOW CHART

We have captured the 27 items
from the National Cancer Survivorship Survey as outcomes
and listed the categories according to the level of concern.
Note. The English titles are original or translated versions
and may differ from the original titles.

Created on: February 1, 2024
Updated on: February 1, 2025

Table Overview

Table Overview

Clicking the button navigates to the corresponding item.

  1. Psychological
    distress
  2. Physical activity maintenance
  3. Fatigue
  4. Communication
  5. Nutrition
  6. Information
  7. Decision-making support
  8. Pain
  9. Surveillance for cancer recurrence and screening for subsequent primary cancers
  10. Financial toxicity
  11. Coordination of care between
    primary care providers and specialists
  12. Sleep disturbance
  13. Return to school/work and employment
  14. Sequelae·Side effects
  15. Appearance
  16. Hormonal therapy–related symptoms, including menopausal disorders
  17. Cardiotoxic
  18. Quality of life (QOL) of the family and the bereaved
  19. Cognitive functioning impairment, including “chemobrain”
  20. Providing information - from healthcare providers
  21. Vaccination
  22. Genetic counseling, Genetic information
  23. Oral care (appropriate oral care for cancer treatment)
  24. Advance Care Planning (ACP)
  25. Assessment, care, and treatment of sexual dysfunction
  26. Moderation in alcohol intake
  27. Smoking cessation
  28. Others

  1. Psychological distress

    Details of intervention Public-funded research
    Survey of suicide number Death by suicide, other externally caused injuries and cardiovascular diseases within 6 months of cancer diagnosis (J-SUPPORT 1902)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All All 6 months after diagnosis Observation MHLW
    Details of intervention Public-funded research
    Cognitive Behavioral Therapy(CBT) Smartphone Psychotherapy Reduces Fear of Cancer Recurrence Among Breast Cancer Survivors: A Fully Decentralized Randomized Controlled Clinical Trial (J-SUPPORT 1703 Study)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Breast cancer 20–49 years >1 year after surgery Intervention AMED
    Details of intervention Public-funded research
    Cognitive Behavioral Therapy(CBT) Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J-SUPPORT 2001 Study)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years >6 months of prognosis Intervention AMED
    Details of intervention Public-funded research
    Peer support ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Guidelines in Japan Guidelines abroad
    JPOS/JASCC guidelines for psychological distress

    Major guidelines with 5+ related CQ
    (Psychological distress)
    • Guidelines for the clinical practice of cancer rehabilitation
    • Guidelines for patient–healthcare provider communication in cancer treatment
    • Guidelines for infusion for patients with terminal cancer
    		 Anxiety, Depression, Trauma, and Distress*2
    Distress Management*3
    Distress Management - Distress During Cancer Care*4

  2. Physical activity maintenance

    Details of intervention Public-funded research
    Rehabilitation Research on the development of an outpatient cancer rehabilitation program
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Gastrointestinal cancer
    Respiratory cancer
    Head and neck cancer
    Breast cancer    		 >20 years Outpatient Program development(pre–post comparison) MHLW·AMED（2016-2018）
    Details of intervention Public-funded research
    Rehabilitation Development of an Outpatient Cancer Rehabilitation Program for Patients with Post-esophageal Cancer Surgery
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Esophageal cancer 20–80 years Postoperative thoracic esophageal cancer Intervention AMED（2022-2024）
    Details of intervention Public-funded research
    Rehabilitation Established Standard Treatment for Cancer-associated Cachexia: Evaluation of the Efficacy of Nutritional and Exercise Therapy Interventions
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Lung cancer
    Pancreatic cancer    		 Older adults Outpatient Intervention MHLW(2016–2018)
    →AMED Follow-up(2019–2021)
    Details of intervention Public-funded research
    Rehabilitation Randomized Phase II Study of Anamorelin Hydrochloride with Nutritional and Exercise Treatment for Cancer Cachexia among Elderly Patients with Advanced Non-small Cell Lung and Pancreatic Cancer (NEXTAC-III study)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Lung cancer
    Pancreatic cancer    		 Older adults Outpatient Intervention AMED(2021–2023:NEXTAC-III)
    Details of intervention Public-funded research
    Rehabilitation Study on the Efficacy and Implementation of Rehabilitation for Cancer Patients Admitted to Palliative Care Wards(D&I)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years Inpatient Intervention AMED（2022-2024）
    Guidelines in Japan Guidelines abroad
    • Guidelines for the clinical practice of cancer rehabilitation
    • Guidelines for plastic surgery practice
    • Guidelines for head and neck reconstruction practice
    • Guidelines for dysphagia treatment
    		 Physical Activity*2
    Survivorship Care for Healthy Living*4

  3. Fatigue

    Details of intervention Public-funded research
    Exercise therapy Established Standard Treatment for Cancer-associated Cachexia: Evaluation of the Efficacy of Nutritional and Exercise Therapy Interventions
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Lung cancer
    Pancreatic cancer    		 Older adults Outpatient Intervention MHLW(2016–2018)
    →AMED Follow-up(2019–2021)
    Details of intervention Public-funded research
    Cognitive Behavioral Therapy(CBT) ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    Guidelines in Japan Guidelines abroad
    • Guidelines for the clinical practice of cancer rehabilitation
    		 Fatigue*2
    Cancer-Related Fatigue*3

  4. Communication

    Details of intervention Public-funded research
    Intention survey Explicit prognostic disclosure to Asian women with breast cancer: A randomized, scripted video-vignette study (J-SUPPORT1601)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Breast Cancer >20 years >1year after surgery Intervention MHLW
    Details of intervention Public-funded research
    Decision-making support Integrated communication support program for oncologists, caregivers and patients with rapidly progressing advanced cancer to promote patient-centered communication: J-SUPPORT 1904 study protocol for a randomized controlled trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Pancreatic cancer >20 years PS0-1 Intervention AMED
    Details of intervention Public-funded research
    Decision-making support
    using IT and
    digital transformation    		 Geriatric assessment and management with question prompt list using a web-based application for elderly patients with cancer (MAPLE) to communicate ageing-related concerns: J-SUPPORT 2101 study protocol for a multicenter, parallel group, randomized controlled trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Esophageal cancer
    Gastric cancer
    Colorectal cancer
    Liver cancer
    Biliary tract cancer
    Pancreatic cancer    		 >70 years Locally advanced stage III, stage IV, or recurrent stage Intervention AMED
    Details of intervention Public-funded research
    Decision-making support
    using IT and
    digital transformation    		 Effectiveness of a facilitation programme using a mobile application for initiating advance care planning discussions between patients with advanced cancer and healthcare providers: protocol for a randomized controlled trial (J-SUPPORT 2104)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Respiratory medicine,
    Gastroenterology,
    Hepatobiliary and Pancreatic medicine, Oncology    		 >20 years PS0-2 Intervention MHLW
    Guidelines in Japan Guidelines abroad
    • JPOS/JASCC guidelines for communication 2022
    • Guidelines for patient-healthcare provider communication in cancer treatment
    		 ー

  5. Nutrition

    Details of intervention Public-funded research
    Nutrition Established Standard Treatment for Cancer-associated Cachexia: Evaluation of the Efficacy of Nutritional and Exercise Therapy Interventions
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Lung cancer
    Pancreatic cancer    		 Older adults Outpatient Intervention MHLW(2016–2018)
    →AMED Follow-up(2019–2021)
    Details of intervention Public-funded research
    Weight maintenance and management ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    Details of intervention Public-funded research
    Eating regimen ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    Details of intervention Public-funded research
    Cancer-related cachexia improvement Elucidating the Pathophysiology of Cachexia Using a Novel Human-derived Model: Establishment and Application of a "Cancer Cachexia PDX Model" for Drug Development and Diagnosis
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ ／ ／ Basic research AMED（2022-2024）
    Guidelines in Japan Guidelines abroad
    • Guidelines for the diagnosis of dysphagia
    		 Nutrition and Weight Management*2

  6. Information(consultation and resource provision)

    Details of intervention Public-funded research
    Consultation/support ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Details of intervention Public-funded research
    Verification of the effectiveness of
    information provision(treatment/systems)    		 ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Guidelines in Japan Guidelines abroad
    ー ー

  7. Decision-making support

    Details of intervention Public-funded research
    Decision-making support Integrated communication support program for oncologists, caregivers and patients with rapidly progressing advanced cancer to promote patient-centered communication: J-SUPPORT 1904 study protocol for a randomized controlled trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Pancreatic cancer >20 years PS0-1 Intervention AMED
    Details of intervention Public-funded research
    Decision-making support Establishing Outcome Indicators in Breast Reconstruction and Evidence-based Decision-making Support for Patients (SAQLA Study)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Breast cancer >20 years Postoperative breast reconstruction Exploratory AMED（2017-2021）
    Details of intervention Public-funded research
    Decision-making support
    using IT and
    digital transformation    		 Geriatric assessment and management with question prompt list using a web-based application for elderly patients with cancer (MAPLE) to communicate ageing-related concerns: J-SUPPORT 2101 study protocol for a multicentre, parallel group, randomised controlled trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Esophageal cancer
    Gastric cancer
    Colorectal cancer
    Liver cancer
    Biliary tract cancer
    Pancreatic cancer    		 >70 years Locally advanced stage III,
    stage IV, or recurrent stage    		 Intervention AMED
    Details of intervention Public-funded research
    Decision-making support
    using IT and
    digital transformation    		 Effectiveness of a facilitation programme using a mobile application for initiating advance care planning discussions between patients with advanced cancer and healthcare providers: protocol for a randomised controlled trial (J-SUPPORT 2104)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Respiratory medicine,
    Gastroenterology,
    Hepatobiliary and Pancreatic medicine, Oncology    		 >20 years PS0-2 Intervention MHLW
    Details of intervention Public-funded research
    Patient empowerment ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Guidelines in Japan Guidelines abroad
    ー ー

  8. Pain

    Details of intervention Public-funded research
    Neuropathic pain Development of evidence-based standard drug therapy for refractory neuropathiccancer pain
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years Refractory neuropathic pain Intervention AMED(2017–2019) JORTC-PAL08
    Details of intervention Public-funded research
    Neuropathic pain International Randomized Controlled Trial of Pregabalin and Duloxetine for Opioid-resistant Neuropathic Pain
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years Refractory neuropathic pain Intervention AMED（2020-2022）
    Details of intervention Public-funded research
    Neuropathic pain Development of Standard Pharmacotherapy for Opioid-refractory Neuropathic Pain in Cancer Patients: An International Collaborative Trial and Research for Dissemination and Implementation
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years Refractory neuropathic pain Intervention AMED（2023-2025）
    Guidelines in Japan Guidelines abroad
    (Pain)
    • Guidelines for the clinical practice of cancer rehabilitation
    • Guidelines for the pharmacological treatment of cancer pain
    • Guidelines for the management of peripheral neuropathy associated with cancer chemotherapy
    		 Pain*2
    Adult Cancer Pain*3
    Details of intervention Public-funded research
    Bone metastases Protocol for a confirmatory trial of the effectiveness and safety of palliative arterial embolization for painful bone metastases
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years Pain scale ≥ 5 Intervention AMED
    Guidelines in Japan Guidelines abroad
    • Guidelines for bone metastasis clinical practice
    		 ー
    Details of intervention Public-funded research
    Development of simple assessment tools ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Guidelines in Japan Guidelines abroad
    ー ー

  9. Surveillance for cancer recurrence and screening for subsequent primary cancers

    Details of intervention Public-funded research
    Consultation for subsequent primary cancers ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Details of intervention Public-funded research
    Reduction of psychological distress and anxiety ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Details of intervention Public-funded research
    Follow-up ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Guidelines in Japan Guidelines abroad
    • Clinical guideline(for each disease)
    • Clinical guideline for pediatric cancer
    		 Survivorship Care for Cancer-Related Late and Long-Term Effects*4

  10. Financial toxicity

    Details of intervention Public-funded research
    Associated factors and psychosocial impacts ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Guidelines in Japan Guidelines abroad
    ー ー

  11. Coordination of care between
    primary care providers and specialists

    Details of intervention Public-funded research
    Cooperative care Encouraging participation in colorectal cancer screening for people with schizophrenia: A randomized controlled trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ >40 years Schizophrenia Intervention MHLW
    Details of intervention Public-funded research
    Cooperative care Geriatric assessment and management with question prompt list using a web-based application for elderly patients with cancer (MAPLE) to communicate ageing-related concerns: J-SUPPORT 2101 study protocol for a multicentre, parallel group, randomised controlled trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Esophageal cancer
    Gastric cancer
    Colorectal cancer
    Liver cancer
    Biliary tract cancer
    Pancreatic cancer    		 >70 years Locally advanced stage III,
    stage IV, or recurrent stage    		 Intervention AMED
    Details of intervention Public-funded research
    Physician collaboration ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    Details of intervention Public-funded research
    Interprofessional collaboration(IC) Nurse-led, Screening-triggered, Early Specialized Palliative Care Intervention Program for Patients with Advanced Lung Cancer: Study Protocol for a Multicenter Randomized Controlled Trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Lung cancer >20 years Stage IV, 1st chemotherapy Intervention AMED
    Details of intervention Public-funded research
    Coordination of care between
    primary care providers and specialists    		 Encouraging participation in colorectal cancer screening for people with schizophrenia: A randomized controlled trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ >40 years Schizophrenia Intervention MHLW
    Guidelines in Japan Guidelines abroad
    ー ー

  12. Sleep disturbance

    Details of intervention Public-funded research
    ー ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    Guidelines in Japan Guidelines abroad
    ー Sleep Disorders*2

  13. Return to school/work and employment

    Details of intervention Public-funded research
    ー ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Guidelines in Japan Guidelines abroad
    • Guideline for brain tumor/pediatric brain tumor
    		 Employment and Return to Work*2

  14. Sequelae·Side effects

    Details of intervention Public-funded research
    Supportive care Phase 3 Randomized Trial of Topical Steroid Versus Placebo for Prevention of Radiation Dermatitis in Patients With Head and Neck Cancer Receiving Chemoradiation.
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Head and neck carcinoma 20-80 years With radiotherapy
    PS0-1    		 Intervention National Cancer Center Research and Development Fund (27-A-3)
    Details of intervention Public-funded research
    Supportive care Preoperative steroid for enhancing patients’ recovery after head and neck cancer surgery with free tissue transfer reconstruction: protocol for a phase III, placebo-controlled, randomised, double-blind study (J-SUPPORT 2022, PreSte-HN Study)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Head and neck carcinoma >20 years With scheduled surgery
    PS0-2    		 Intervention AMED
    Details of intervention Public-funded research
    Supportive care Study on Establishing Methodology in Supportive and Palliative Care Research
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ ／ ／ Research method development AMED（2017-2018）
    Details of intervention Public-funded research
    Supportive care Non-randomized confirmatory trial of postoperative concurrent chemoradiotherapy (CCRT) using IMRT for patients with high-risk uterine cervical cancer
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Uterine cancer 20-70 years StageIB1-IIB
    PS0-1    		 Intervention AMED（2019-2020）
    Details of intervention Public-funded research
    Supportive care Observational study to develop a Support program for Cancer patients undergoing a comprehensive cancer genomic profiling testing and Advanced Therapeutics (S-CAT)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >18 years With scheduled genome exams Observation AMED（2022-2024）
    Details of intervention Public-funded research
    Supportive care Study on the Standardization of Research Methodology in Supportive and Palliative Care Involving Multiple Stakeholders
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ ／ ／ Research method development AMED（2022-2024）
    Guidelines in Japan Guidelines abroad
    (Supportive care)
    • Guidelines for the infusion of patients with terminal cancer
    • Clinical guidelines for lung cancer
    • Peritoneal metastasis
    		 ー
    Details of intervention Public-funded research
    Prospective cohort of comprehensive
    support and palliative care    		 A Prospective Cohort Study on Comprehensive Supportive and Palliative Care for Patients with Retinoblastoma and Their Families
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Retinoblastoma 0-5 years Within 1 month after diagnosis Observation AMED（2023-2024）
    Guidelines in Japan Guidelines abroad
    • Pediatric cancer clinical practice guidelines
    		 ー
    Details of intervention Public-funded research
    Hemostasis Multicenter prospective observational study on the effectiveness of palliative radiotherapy for gastric cancer with bleeding (JROSG 17-3)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Gastric cancer >20 years Bleeding from the primary tumor Observation JROSG
    Guidelines in Japan Guidelines abroad
    ー Gastric Cancer. 2022 Mar;25(2):411-421.
    Details of intervention Public-funded research
    Cancer immunity ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    • No current guideline information available.
    Details of intervention Public-funded research
    Oncology ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    • No current guideline information available.
    Details of intervention Public-funded research
    Oncology emergency ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    • No current guideline information available.
    Details of intervention Public-funded research
    Kampo medicine A double-blind randomized controlled trial to verify the improvement effect of Hangeshashinto on oral mucositis and blood metabolome analysis to clarify biomarkers, Kampo medicine's proof, and to contribute to appropriate use of Kampo medicines
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Head and neck carcinoma >18 years With radiotherapy 1)Observation
    2)Intervention    		 AMED（2021-2023）
    • No current guideline information available.
    Details of intervention Public-funded research
    Fertility Clinical Study on Standardizing Psychological Support Systems for Fertility Preservation to Enhance Survivorship in Pediatric and AYA Cancer
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Breast cancer 20-39 years Fertility preservation–related decision-making Intervention MHLW(2017-2019)
    Details of intervention Public-funded research
    Fertility Establishment of a Comprehensive Platform for the Innovative Advancement of Fertility-Preserving Cancer Therapies
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >40 years Fertility preservation–related decision-making ― AMED（2016-2018）
    Guidelines in Japan Guidelines abroad
    (Fertility)
    • Guidelines for uterine cancer treatment
    • Guidelines for fertility preservation
    • Guidelines for pregnancy, childbirth, and reproductive medicine for patients with breast cancer
    • Guidelines for the treatment of ovarian, fallopian tube, and peritoneal cancer
    		 ー
    Details of intervention Public-funded research
    Onco-nephrology ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    • No current guideline information available.
    Details of intervention Public-funded research
    Nausea and vomiting Olanzapine 5 mg plus standard antiemetic therapy for the prevention of chemotherapy-induced nausea and vomiting (J-FORCE): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All
    (excluding hematological malignancies)    		 20-75 years Cisplatin chemotherapy Intervention AMED
    Details of intervention Public-funded research
    Nausea and vomiting Dexamethasone-sparing on days 2-4 with combined palonosetron, neurokinin-1 receptor antagonist, and olanzapine in cisplatin: a randomized phase III trial (SPARED Trial)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years Cisplatin chemotherapy Intervention AMED（2019-2021）
    Details of intervention Public-funded research
    Nausea and vomiting Effect of Rikkunshito (Kampo medicine) on Nausea and Vomiting in Patients with Cervical Cancer Receiving Cisplatin-based Chemotherapy: A Placebo-controlled, Randomized, Double-blind Trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Cervical cancer
    Endometrial cancer    		 >20 years Cisplatin chemotherapy Intervention AMED（2018）
    →（2019-2021）
    Details of intervention Public-funded research
    Nausea and vomiting Study on Establishing Methodologies across Various Fields in Clinical Trials for Supportive and Palliative Care
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ ／ ／ Research method development AMED（2017-2018）
    →（2019-2021）
    Guidelines in Japan Guidelines abroad
    (nausea, vomiting)
    • Guidelines for the proper use of antiemetic drugs
    		 ー
    Details of intervention Public-funded research
    Lymphedema ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    Guidelines in Japan Guidelines abroad
    (Lymphedema)
    • Cancer rehabilitation treatment guidelines
    • Lymphedema treatment guidelines
    		 Lymphedema*2
    Details of intervention Public-funded research
    Hand–foot syndrome, dermatopathy Hydrocolloid dressing as a prophylactic use for hand–foot skin reaction induced by multitargeted kinase inhibitors: protocol of a phase 3 randomised self-controlled study
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Colorectal cancer
    Gastrointestinal stromal tumor
    Hepatocellular carcinoma     		>20 years With multi-kinase inhibitors Intervention Kimura Foundation For Nursing Education
    Guidelines in Japan Guidelines abroad
    (Hand–foot syndrome, dermatopathy)
    • Guidelines for appearance care for cancer treatment
    • Clinical guidelines for Head and neck cancer
    • Clinical guidelines for plastic surgery
    		 ー
    Details of intervention Public-funded research
    Mucositis Study on Establishing Methodologies across Various Fields in Clinical Trials for Supportive and Palliative Care
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ ／ ／ Research method development AMED（2017-2018）
    →（2019-2021）
    • No current guideline information available.
    Details of intervention Public-funded research
    Neurologic disorders ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    Guidelines in Japan Guidelines abroad
    • Guidelines for the management of peripheral neuropathy associated with cancer chemotherapy
    		 ー
    Details of intervention Public-funded research
    Numbness ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    Guidelines in Japan Guidelines abroad
    • Guidelines for the management of peripheral neuropathy associated with cancer chemotherapy
    		 ー
    Details of intervention Public-funded research
    Neutropenia ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    • No current guideline information available.
    Details of intervention Public-funded research
    Constipation and diarrhea ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    • No current guideline information available.
    Details of intervention Public-funded research
    Stoma ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    • No current guideline information available.
    Details of intervention Public-funded research
    Pneumonitis, breathing disorders Feasibility Randomized, Placebo-controlled Trial of the Efficacy of Midazolam as the Second-line Treatment for Dyspnea in Patients with Advanced Cancer
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >18 years Without aggressive chemotherapy Intervention KAKENHI
    • No current guideline information available.
    Details of intervention Public-funded research
    Pneumonitis, breathing disorders Study on Establishing Methodologies across Various Fields in Clinical Trials for Supportive and Palliative Care
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ ／ ／ Research method development AMED（2017-2018）
    →（2019-2021）
    • No current guideline information available.

  15. Appearance

    Details of intervention Public-funded research
    Appearance care Development of the evaluation methods and the standard skin care for the skin changes in cancer therapy
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Lung cancer
    Colorectal cancer    		 >20 years With EGFR inhibitor treatment, etc. Intervention AMED（2017-2018）
    Guidelines in Japan Guidelines abroad
    • Appearance care guidelines for cancer treatment
    		 ー

  16. Hormonal therapy–related symptoms, including menopausal disorders

    Details of intervention Public-funded research
    Hormonal therapy–related symptoms
    (e.g., Hot flashes)    		 ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    Guidelines in Japan Guidelines abroad
    • Guidelines for cervical cancer treatment
    		 Hormone-Related Symptoms*2
    Hot Flashes and Night Sweats (PDQ®)

  17. Cardiotoxic

    Details of intervention Public-funded research
    Oncology cardiovascular medicine Prospective single-center study of multimodality imaging and omics data analysis to evaluate cardiac function and risk factors in breast cancer patients treated with chemothrapy
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Breast Cancer >20 years With a risk of drug-induced cardiomyopathy Observation AMED（2019-2020）
    Details of intervention Public-funded research
    Oncology cardiovascular medicine Exploratory Study on Screening Methods and Risk Factors for Myocardial Damage as Immune-related Adverse Events (irAE) to Promote the Safe Use of Immune Checkpoint Inhibitors
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All ／ With Myocarditis Observation AMED（2020-2022）
    Details of intervention Public-funded research
    Influence of multidrug use ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー AMED（2020-2022）
    Guidelines in Japan Guidelines abroad
    ー Cardiovascular Disease Risk Assessment,
    Anthracycline-Induced Cardiac Toxicity*2

  18. Quality of life (QOL) of the family and the bereaved

    Details of intervention Public-funded research
    Care for family Developmental Study on Effective Psychosocial Support Methods for Families and the Bereaved of Cancer Patients
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ >20 years Family, bereaved Research method development MHLW(2019-2021)
    Details of intervention Public-funded research
    Care for family Patient Experience Survey*5
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >19 years Patient with cancer Observation ／
    • *5Patient Experience Survey Report (FY 2018 Survey)': Family Proxy Response Rate: 21%, Question 30-2: ”There are sufficient support services, resources, or places where families of cancer patients can discuss their concerns and burdens"- 47.7%, Question 19: Response to Financial Burden - "Family members increased work hours or started working to increase income" - 1.8%"
    Details of intervention Public-funded research
    Grief care Developmental Study on Effective Psychosocial Support Methods for Families and the Bereaved of Cancer Patients
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ >20 years Family, Bereaved Research method development MHLW(2019-2021)
    Details of intervention Public-funded research
    Grief care Survey of Bereaved Families*6
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years Bereaved Observation ／
    • *6Survey Report for Bereaved Families on the Medical Care Received by Patients (FY 2018-2019): "There was a discussion between the family and the physician regarding resuscitation procedures in the event of cardiopulmonary arrest" - 56.1%, Caregiving Burden of the family (overall, physical, social, mental, economic) - 33-46%, Depression of family members - 19%, Severe Grief 30%
    Guidelines in Japan Guidelines abroad
    JPOS/JASCC bereaved guidelines 2022
    (Family care)
    • No guidelines applicable
    (Grief care)
    • Guidelines for infusion of terminal cancer patients
    • Bereaved care guidelines
    		 ー
    Details of intervention Public-funded research
    Prospective cohort of comprehensive
    support and palliative care    		 A Prospective Cohort Study on Comprehensive Supportive and Palliative Care for Patients with Retinoblastoma and Their Families
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Retinoblastoma 0–5 years Within 1 month after diagnosis Observation AMED（2023-2024）
    Guidelines in Japan Guidelines abroad
    • Clinical practice guidelines for pediatric cancer
    		 ー

  19. Cognitive functioning impairment, including “chemobrain”

    Details of intervention Public-funded research
    Dementia and delirium Yokukansan for Treatment of Preoperative Anxiety and Prevention of Postoperative Delirium in Cancer Patients Undergoing Highly Invasive Surgery. J-SUPPORT 1605 (ProD Study): A Randomized, Double-Blind, Placebo-Controlled Trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years With >6 h of surgery Intervention The others
    Details of intervention Public-funded research
    Dementia and delirium A multi-centre, double-blind, randomized, placebo-controlled trial to evaluate the effectiveness and safety of ramelteon for the prevention of postoperative delirium in elderly cancer patients
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >65 years Surgery with general anesthesia and >5 days of hospitalization Intervention AMED
    Details of intervention Public-funded research
    Dementia and delirium Quality of care in hospitalized cancer patients before and after implementation of a systematic prevention program for delirium: the DELTA exploratory trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ >70 years High risk for delirium Intervention AMED(2016–2017)
    Details of intervention Public-funded research
    Dementia and delirium Development of Biomarkers to Predict Severe Delirium Unresponsive to Dexmedetomidine Sedation Following Surgical Cancer Resection
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ ／ ／ Observation AMED(2018-2020)
    Details of intervention Public-funded research
    Dementia and delirium Exploratory Research on Factors Related to Difficulty in Decision Making in Elderly Patients with Cancer
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All Older adults With cognitive impairment Exploratory AMED（2017-2019）
    Details of intervention Public-funded research
    Dementia and delirium Development of Precision Medicine for Preventing Postoperative Delirium in Cancer Patients
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years High risk for postoperative delirium Exploratory AMED（2022-2024）
    Details of intervention Public-funded research
    Delirium-related psychological trauma ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Guidelines in Japan Guidelines abroad

    JPOS/JASCC Delirium Guideline 2022

    (Cognitive dysfunction)
    • Practice guidelines for cancer rehabilitation
    		 Cognitive Function*2

  20. Providing information - from healthcare providers

    Details of intervention Public-funded research
    Second opinion ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    Guidelines in Japan Guidelines abroad

    JPOS/JASCC Delirium Guidelines 2022

    （CST for physicians）
    • Guidelines for Communication
    • Guidelines for the infusion of patients with terminal cancer

    CST = Communication Skills Training

    		 Cognitive Function*2

  21. Vaccination

    Details of intervention Public-funded research
    Vaccination ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Details of intervention Public-funded research
    COVID-19 vaccination A Study on Health Inequality Assessment Regarding the COVID-19 Issue and General Society in Japan
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ >20 years ／ Observation MHLW
    AMED
    Guidelines in Japan Guidelines abroad
    (Immunization and infection prevention)
    • Clinical guidelines for pediatric leukemia and lymphoma
    (Only one item)
    • Breast cancer clinical guidelines: Recommendations for vaccination
    		 Immunizations and Infections*2

  22. Genetic counseling, Genetic information

    Details of intervention Public-funded research
    Genetic counseling,
    Genetic information    		 Observational study to develop a Support program for Cancer patients undergoing a comprehensive cancer genomic profiling testing and Advanced Therapeutics (S-CAT)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >18 years Scheduled genomic exam Observation AMED（2022-2024）
    Guidelines in Japan Guidelines abroad
    • HBOC clinical practice guidelines
    • Clinical guidelines for fertility preservation in pediatric, adolescent, and young-adult patients with cancer
    • Clinical guidelines for pancreatic cancer
    		 Genetic/Familial High-Risk Assessment
    (Colorectal, Breast, Ovarian, Pancreatic)*3

  23. Oral care(appropriate oral care for cancer treatment)

    Details of intervention Public-funded research
    Oral care A double-blind randomized controlled trial to verify the improvement effect of Hangeshashinto on oral mucositis and blood metabolome analysis to clarify biomarkers, Kampo medicine's proof, and to contribute to appropriate use of Kampo medicines
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Head and neck carcinoma >18 years With radiotherapy 1) Observation
    2) Intervention    		 AMED（2021-2023）
    Details of intervention Public-funded research
    Oral care Development of a Novel Oral Mucosal Protectant Aimed at Pain Relief and Prevention of Oral Mucositis Associated with Cancer Chemotherapy
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ ／ ／ Basic research AMED（2020-2021）
    Guidelines in Japan Guidelines abroad
    • Guidelines for plastic surgery (head and neck reconstruction)
    • Guidelines for oral cancer treatment
    		 ー

  24. Advance Care Planning (ACP)

    Details of intervention Public-funded research
    Decision-making support Integrated communication support program for oncologists, caregivers and patients with rapidly progressing advanced cancer to promote patient-centered communication: J-SUPPORT 1904 study protocol for a randomized controlled trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Pancreatic cancer >20 years PS0-1 Intervention AMED
    Details of intervention Public-funded research
    Decision-making support
    using IT and
    digital transformation    		 Effectiveness of a facilitation programme using a mobile application for initiating advance care planning discussions between patients with advanced cancer and healthcare providers: protocol for a randomized controlled trial (J-SUPPORT 2104)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Cancer-related
    pulmonology/gastroenterology/hepatobiliary/ oncology department    		 >20 years PS0-2 Intervention MHLW
    Guidelines in Japan Guidelines abroad
    • Guidelines for communication
    • Guidelines for infusion in patients with terminal cancer
    		 ー

  25. Assessment, care, and treatment of sexual dysfunction

    Details of intervention Public-funded research
    Sexual functions ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ―
    Guidelines in Japan Guidelines abroad
    • Guidelines for prostate cancer practice
    		 Sexual Function*2

  26. Moderation in alcohol intake

    Details of intervention Public-funded research
    Drinking of alcohol sparingly ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Guidelines in Japan Guidelines abroad
    • Guidelines for esophageal cancer treatment
    • Guidelines for cervical cancer treatment
    		 ー

  27. Smoking cessation

    Details of intervention Public-funded research
    Smoking cessation ー
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ー ー ー ー ー
    Guidelines in Japan Guidelines abroad
    • Guidelines for esophageal cancer treatment
    • Guidelines for cervical cancer treatment
    • Guidelines for renal cancer treatment
    		 Smoking Cessation*3

  28. Others

    Details of intervention Public-funded research
    Patient-reported
    Outcome(PRO)    		 Clinical research in the development of patient reported outcome measures for cancer patients
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years ／ Scale development AMED（2019-2021）
    • No current guideline information available.
    Details of intervention Public-funded research
    Electronic informed consent Study on the Standardization of Research Methodology in Supportive and Palliative Care Involving Multiple Stakeholders
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ ／ ／ Research method development AMED（2022-2024）
    • No current guideline information available.
    Details of intervention Public-funded research
    Digital health Smartphone Psychotherapy Reduces Fear of Cancer Recurrence Among Breast Cancer Survivors: A Fully Decentralized Randomized Controlled Clinical Trial (J-SUPPORT 1703 Study)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Breast Cancer 20–49 years 1 year after surgery Intervention AMED
    • No current guideline information available.
    Details of intervention Public-funded research
    Digital health Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J-SUPPORT 2001 Study)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All >20 years >6 months prognosis Intervention AMED
    • No current guideline information available.
    Details of intervention Public-funded research
    Work-environment intervention Interactive assistance via eHealth for small- and medium-sized enterprises’ employer and health care manager teams on tobacco control (eSMART-TC)
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ >20 years 30–300 employees form medium- or small-sized companies Intervention KAKENHI
    • No current guideline information available.
    Details of intervention Public-funded research
    Health disparities Encouraging participation in colorectal cancer screening for people with schizophrenia: A randomized controlled trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ >40 years Schizophrenia Intervention MHLW
    • No current guideline information available.
    Details of intervention Public-funded research
    Medical examination Encouraging participation in colorectal cancer screening for people with schizophrenia: A randomized controlled trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    ／ >40 years Schizophrenia Intervention MHLW
    • No current guideline information available.
    Details of intervention Public-funded research
    Healthcare quality assessment Quality of palliative care for end-of-life cancer patients and retrospective cohort study of unsolved clinical question of palliative care from administrative claims data
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    All All Cancer death Observation AMED（2016-2018）
    • No current guideline information available.
    Details of intervention Public-funded research
    Geriatrics and cancer
    treatment for older adults    		 Geriatric assessment and management with question prompt list using a web-based application for elderly patients with cancer (MAPLE) to communicate ageing-related concerns: J-SUPPORT 2101 study protocol for a multicenter, parallel group, randomized controlled trial
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Esophageal cancer
    Gastric cancer
    Colorectal cancer
    Liver cancer
    Biliary tract cancer
    Pancreatic cancer    		 >70 years Locally advanced stage III,
    stage IV, or recurrent stagePS0-2    		 Intervention AMED
    Details of intervention Public-funded research
    Geriatrics and cancer
    treatment for older adults    		 Multicenter Clinical Trial Using Functional Assessment Tools for Older-adult Patients with Lung Cancer
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Lung cancer Older adults Incapable of surgery Intervention AMED（2022-2024）
    Details of intervention Public-funded research
    Geriatrics and cancer
    treatment for older adults    		 Established Standard Treatment for Cancer-associated Cachexia: Evaluation of the Efficacy of Nutritional and Exercise Therapy Interventions
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Lung cancer
    Pancreatic cancer    		 Older adults Outpatient Intervention MHLW(2016–2018)
    →AMED Follow-up(2019–2021)
    Details of intervention Public-funded research
    Geriatrics and cancer
    treatment for older adults    		 Randomized Phase III Trial of Reduced-Starting-Dose S-1 Adjuvant Chemotherapy for 'Vulnerable' Older adults Patients Aged 80 and Over with Pathological Stage II/III Gastric Cancel
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Gastric cancer Older adults StageII/III Intervention AMED（2020-2022）
    • No current guideline information available.
    Details of intervention Public-funded research
    Pediatric and adolescent and young adult (AYA) Clinical Study on Standardizing Psychological Support Systems for Fertility Preservation to Enhance Survivorship in Pediatric and AYA Cancer
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Breast cancer 20–39 years Decision-making regarding fertility preservation Intervention MHLW(2017-2019)
    • No current guideline information available.
    Details of intervention Public-funded research
    Pediatric and adolescent and young adult (AYA) A Prospective Cohort Study on Comprehensive Supportive and Palliative Care for Patients with Retinoblastoma and Their Families
    Cancer type Generation Back ground Research type Research funds
    (mainly public research funding)
    Retinoblastoma 0–5 years Within one month after diagnosis Observation AMED（2023-2024）
    Guidelines in Japan Guidelines abroad
    • Clinical practice guidelines for pediatric cancer
    		 ー

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